Saint Vincent and the Grenadines has promoted universal adherence to the treaty, including by co-sponsoring a UN General Assembly resolution in 2019 that calls upon all states to sign, ratify, or accede to the treaty “at the earliest possible date”.

In a statement to the United Nations in September 2019, the prime minister of Saint Vincent and the Grenadines, Ralph Gonsalves, encouraged all states that have not yet ratified the treaty “to do so in our collective pursuit to bring peace to every corner of the globe”.

In 2016, Saint Vincent and the Grenadines was an additional co-sponsor of the UN General Assembly resolution that established the formal mandate for states to commence the negotiations in 2017 on “a legally binding instrument to prohibit nuclear weapons, leading towards their total elimination”.

Saint Vincent and the Grenadines was among 127 states that endorsed a “humanitarian pledge” in 2015–16 to cooperate “in efforts to stigmatise, prohibit, and eliminate nuclear weapons”. The pledge was instrumental in building momentum and support for convening the negotiations.

Saint Vincent and the Grenadines is a state party to the 1967 Treaty of Tlatelolco, which established Latin America and the Caribbean as a nuclear-weapon-free zone.